![]() In it, David Sinclair says that pterostilbene is essentially resveratrol plus three methyl groups, which adds the substantial benefit of it also being an NAD+ booster. ![]() Listen to David Sinclair speak about pterostilbene and resveratrol in this short clip. Various studies show that pterostilbene works better than resveratrol regarding anticancer, antidiabetic, and cardioprotective effects ( R, R, R). This increases the bioavailability, and enhances the pharmacokinetic profile and pharmacological activities of pterostilbene” ( R).įurther, pterostilbene contains three methyl groups that resveratrol doesn’t, which the body can use for, among other things, methylation, which is required for proper gene function. For example, a paper that compares resveratrol to pterostilbene states, “Although there are structural and bioactivity similarities between resveratrol and pterostilbene, pharmacological properties of pterostilbene are often stronger than those of resveratrol,” and “Overall, pterostilbene performs better in membrane permeability and metabolic stability than resveratrol. Pterostilbene is a molecule that looks very similar to resveratrol, but it is absorbed considerably better and is far more stable in the human body. Therefore, pterostilbene is a better alternative. ![]() However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins. Studies have shown that resveratrol can reduce the risk of heart disease, cancer, and neurodegeneration.ĭavid Sinclair believes that resveratrol works synergistically with NMN. Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Our view: We are lukewarm about resveratrol.
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